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Job Description

We are looking for highly motivated and talented individual with passion in oncology and genomics research to join the Precision Radiation Oncology Program and the Data and Computational Science Core at the National Cancer Centre Singapore. You will primarily work with the Principal Investigator (PI) and the current research and clinical teams. The selected individual is expected to contribute actively to our genomics and radiomics research that is focused on using electronic medical records, next-generation sequencing (NGS) and radiological imaging datasets to developing biomarkers predictive of clinical responses in cancer patients. Specifically, the Research Fellow will be expected to perform genomics and radiomics data processing, statistical analyses, feature extraction for statistical/machine learning and survival analysis, and other relevant computational analyses to better understand the complexity of cancer progression and treatment resistance of head and neck and prostate cancers. You will also be required to guide research discussions with other scientists and mentor students. There will also be ample opportunities for inter-departmental and cross-institution collaborations with oncologists, pathologists, and scientists.

Job Requirements

• PhD in Computational Biology or Computer Science or Mathematics or Biostatistics or Biophysics

• Highly motivated, organised, meticulous and committed to high quality standards

• Prior experience in handling data sets (e.g. data curation, cleaning and organisation)

• Competency in python/R or other computing language (Good to have)

• Demonstrable data analysis skills with a portfolio on relevant datasets (e.g. TCGA, Kaggle)

• Familiarity with command line shells (e.g. bash, zsh)

• Prior experience working with high-performance computing clusters and job schedulers

• Knowledge and experience in biostatistical analyses of clinical datasets

• Knowledge and experience in genomics analyses (e.g. analyses of WES, RNASeq data)

• Able to work independently under pressure as well as in a team

• Strong organizational, interpersonal and presentation skills

• Responsible, analytical and self-confident with a mature personality

• Keen interest to solve clinical problems.

Job Description

We are looking for a highly motivated and talented individual with passion in cancer genomics, biology and radiation research to join the Tan Chin Tuan Laboratory of Optical Imaging, Photodynamic and Proton Therapy - Precision Radiation Oncology Programme (PROP). The scope of the projects conducted under the premise of PROP includes 1) early- and late-phase clinical trials; 2) cancer genomics and data science; and 3) translational cancer and radiation biology. For this role, you will be mainly working with the Principal Investigator (PI) and the research teams under Themes 2 and 3. The projects involve studying cancer genomics of two main cancers, nasopharyngeal and prostate cancer, and the development of novel nanoparticle-based cancer therapeutics.  Samples from consented patients will be used for next generation sequencing and/or microarray to generate “big data” for further analysis by our data scientists, while cell lines and animal xenograft models will be used to test the efficacy and toxicity of novel therapeutics. You will be involved in inter-departmental collaborations with oncologists, pathologists, scientists, and local and international collaborators.  

You will be expected to perform the following activities:

• Processing and multi-omics molecular profiling of patient samples, including next generation sequencing, microarray analysis, etc.

• Designing experiments to evaluate biological response in cancer cells and mouse xenograft tumours following various cancer therapies, including nanoparticle-based drug delivery, x-ray/proton radiation, photodynamic therapy.

• Generating and characterising immunodeficient/immunocompetent mouse models of cancers.

• Designing and optimising new experiment protocols when necessary.

• Maintaining a complete and updated biobank and database of collected patient samples and perform QA/QCs to ensure excellent and consistent sample and data quality.

• Mechanistically validate genetic discoveries from next generation sequencing experiments.

• Maintain inventory and purchase reagents, consumables and equipment when required.

• Lead and mentor junior staff and students to assist in the above activities.

• Assist PI/co-investigators in preparing grant reports, manuscripts and reviews for publication, and grant/patent applications.

• Actively engage internal clinical and data science teams as well as external collaborators to ensure alignment with overall research goals.

• Participate in lab meetings, conferences, manuscript preparations and audits.

Job Requirements

• PhD/Masters degree in Biomedical/Life Sciences, or related fields.

• At least 3 years of research experience in molecular biology or genomics is necessary.

• Must be comfortable with handling blood, tissue samples and live animals.

• Leadership, strong initiative and good communications skills are necessary.

• Strong organization skills and attention to detail in database management are necessary.

• Strong technical wet lab skills are necessary.

• Able to work both independently and with other team members under pressure and tight deadlines.

• Skills in molecular and cellular biological techniques, including western blot, PCR, DNA/RNA extraction for next generation sequencing will be a plus.

• Skills in techniques related to mouse work, including live (aseptic) surgery, drug delivery (via i.v., oral or peritoneal routes), blood collection (via cardiac puncture or retro orbital routes), serological assays, cryosectioning, paraffin sectioning, IHC staining, H&E staining will be a plus.